cytoscape assign colors to different clusters

In this study, we aimed to clarify protein-protein interactions of EAC by network analysis. These findings can be used in interpretation of played roles of the proteins in onset and development of any diseases (Goh et al., 2007 Barabási et al., 2011 Özgür et al, 2008 Safaei et al., 2016). Gene ontology analysis can be used to determine underlying biological processes, molecular function, cellular component and biochemical pathways relative to the proteins. These key proteins interact with the large numbers of the nodes of network and considerable types of their connections are as shortest lengh paths so they are called hub-bottleneck proteins (Goh et al., 2007 Safaei et al., 2016). Crucial nodes of network are the important proteins related to the studied disease (Safari-Alighiarloo et al., 2016 Zamanian-Azodi et al., 2015). Topological analysis of network provide useful information about roles of the initial proteins (nodes) in the nework (Safari-Alighiarloo et al., 2014 Moreau and Tranchevent, 2012 Safari-Alighiarloo et al., 2016). In this method, many proteins implicated to a certain disease reterived and atribute in an interactive structure (PPI network) (Liu et al., 2014 Safari-Alighiarloo et al., 2014 Abbaszadeh et al., 2017). PPI network analysis as an attracting method is used for molecular assesment of many diseases (Shannon et al., 2003 Massoud and Gambhir, 2007). Undrestanding a network containing proteins, and generalized an existing computational methods were used to identify related disease proteins simultaneously (Gao et al., 2015). Attempts to clarify the mechanism underlying esophageal cancer by searching for novel proteins and proteins interactions are attractive recently. There has been a lack of systematic analysis of the molecular markers that characterize protein of EAC. It is important to understand the molecular mechanism in the tumor invasion process to assist finding new biomarkers for early diagnosis and prognostic evaluation (Fu et al., 2007). The majority of EAC patients present with advanced metastatic disease upon diagnosis (Rubenstein and Shaheen, 2015). Henan province of northern china has the highest incidence and mortality of EAC in the world (Ke, 2002). EAC is the sixth most common cancer among males and ninth most common cancer among females globally (Guo and Jiang, 2009). It has been reported the rapid increament in the incidence of EAC among white men (Brown et al., 2008). The incidence of esophageal adenocarcinoma has been increased dramatically over the past 25 years (Brown and Devesa, 2002) and it perhaps represents a true rise in disease burden (Pohl and Welch, 2005). Based on selected registries, the highest esophageal cancer incidence rates are in Malawi, South Africa, and Iran (Torre et al., 2016).

In 2012, it is estimated that 455,800 esophageal cancer cases and 400,200 deaths are occurred in the word. EAC ranked as the sixth leading cause of cancer death in the world (Parkin et al., 2001). Esophageal adenocarcinoma is one of the most common malignancies in the world with a very poor prognosis.

Cytoscape assign colors to different clusters